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Cannabidiol (CBD) is one the natural product obtained from cannabis species which is free of psychoactive side effects hence useful in the treatment of epilepsy. Tetrahydrocannabinol (THC) is an another related cannabinoid which acts as partial agonist on cannabinoid receptors therefore shows psychoactive symptoms like hallucinations and drug addiction. On the other hand, CBD acts as allosteric antagonist thereby it doesn’t produce such side effects. Antiepileptic action of CBD is mainly due to its inhibitory effect of TRPV1 ion channels and GPR55 receptors. Its agonist action of 5-HT1A receptors and other actions also result in antiepileptic activity.