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In our actual physiology where does CBD work? We are going to travel into our physiology. Right into our central nervous system. We are going to see at the level of individual cells that the cell surface is covered with these green receptors. These are receptors for CBD. When the CBD binds to that receptor it sends a message into the cell which travels all the way down into the nucleus of the cell where the intelligence of our entire physiology is contained in our chromosomes. Here a chromosome will unwind and you are going to see the DNA that contains the codes for everything that our body does. This is like the software that runs our physiology. Genes are the codes for every protein that our bodies make. Including all the signaling molecules that run our physiology. Such as our neurotransmitters that run our nervous system. Our hormones that run our endocrine system and our cytokines that run our immune system.
So we see that throughout our physiology we have receptors specifically designed to bind with cannabidiol and CBD has its effect on the nucleus of our cells where proteins are being made. Cannabidiol modulates the transcription of over 1100 genes that make the signaling molecules that naturally reduce inflammation in our central nervous system and throughout our immune system. Restoring homeostasis to both our immune and central nervous systems.
Bottom line… One of the benefits of cannabidiol is that it causes a cascade of Homeostasis through our entire central nervous system and our entire immune system. Why is this happening? As I mentioned before we have receptors in our body for CBD. This is called the endo-cannabinoid system. Back in medical school we didn’t’t even know about the endo-cannabinoid system. It was discovered in the 1990’s by Dr. Rafael Mechoulan from the Hebrew University in Israel. So the endo-cannabinoid system is a network of cells throughout our body that have receptors for CBD. In fact, there are more receptors for CBD in our body than any other kind of receptor. So the endo-cannabinoid system is truly the largest network of its kind throughout our entire physiology. Among other things Dr. Mechoulam also discovered that we make our own cannabinoids in or body. This is Anandamide and 2AG. Those two are natural cannabinoids that our bodies make and bind to our CBD receptors. Our bodies are filled with CBD receptors.
What kind of symptoms what kind of stress do all these things cause to us? If your immune system is inflamed you might be suffering from autoimmune diseases like rheumatoid arthritis, inflamed bowel disease, lupus and thyroid. Or fibromyalgia or even multiple sclerosis. And you skin, psoriasis and eczema and all sorts of other chronic infections. Do you realize that many of things didn’t even exist 100 or 150 years ago. Incidences of these sorts of diseases is growing throughout the last century.
Now lets take a look at your central nervous system. If it is inflamed what types of things might you be suffering from? Brain fog, migraines, epilepsy, anxiety and PTSD, ADD, ADHD, autism and insomnia. Again, 100 or 150 years ago these kinds of symptoms, these kind of diseases where rare. If you are suffering from any of these conditions, any of these symptoms, CBD might provide you with tremendous healing, tremendous relief, right through your own natural endo-cannabinoid system that brings homeostasis both to your immune system and to your central nervous system.
In conclusion, what have we learned from this conversation? That health is achieved through physiological homeostasis right through our natural endo-cannabinoid systems. Therefore, CBD is an indispensable catalyst for optimal health.
AMA Regenerative Medicine & Skincare
Alice Pien, MD
Asher Milgrom, PhD
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